Serum fibronectin distinguishes the early stages of hepatocellular carcinoma
Identifieur interne : 000187 ( Main/Exploration ); précédent : 000186; suivant : 000188Serum fibronectin distinguishes the early stages of hepatocellular carcinoma
Auteurs : Hyunsoo Kim [Corée du Sud] ; Jiyoung Park [Corée du Sud] ; Yongkang Kim [Corée du Sud] ; Areum Sohn [Corée du Sud] ; Injun Yeo [Corée du Sud] ; Su Jong Yu [Corée du Sud] ; Jung-Hwan Yoon [Corée du Sud] ; Taesung Park [Corée du Sud] ; Youngsoo Kim [Corée du Sud]Source :
- Scientific Reports [ 2045-2322 ] ; 2017.
Abstract
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death, necessitating the discovery of serum markers for its early detection. In this study, a total of 180 serum samples from liver cirrhosis (LC), hepatocellular carcinoma (HCC) patients and paired samples of HCC patients who recovered (Recovery) were analyzed by multiple reaction monitoring-mass spectrometry (MRM-MS) to verify biomarkers. The three-fold crossvalidation was repeated 100 times in the training and test sets to evaluate statistical significance of 124 candidate proteins. This step resulted in 2 proteins that had an area under the receiver operating curve (AUROC) values ≥0.800 in the training (n = 90) and test sets (n = 90). Specifically, fibronectin (FN1, WCGTTQNYDADQK), distinguished HCC from LC patients, with an AUROC value of 0.926 by logistic regression. A FN1 protein was selected for validation in an independent sample (n = 60) using enzyme-linked immunosorbent assay (ELISA). The combination of alpha-fetoprotein (AFP) and FN1 improved the diagnostic performance and differentiated HCC patients with normal AFP levels. Our study has examined candidate markers for the benign disease state and malignancy and has followed up on the consequent recovery. Thus, improvement in the early detection of HCC by a 2-marker panel (AFP + FN1) might benefit HCC patients.
Url:
DOI: 10.1038/s41598-017-09691-3
PubMed: 28842594
PubMed Central: 5573357
Affiliations:
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5905</institution-id><institution-id institution-id-type="GRID">grid.31501.36</institution-id><institution>Department of Biomedical Sciences,</institution><institution>Seoul National University College of Medicine, Yongon-Dong,</institution></institution-wrap>Seoul, 110-799 Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Seoul</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0470 5905</institution-id><institution-id institution-id-type="GRID">grid.31501.36</institution-id><institution>Department of Biomedical Engineering,</institution><institution>Seoul National University College of Medicine, Yongon-Dong,</institution></institution-wrap>Seoul, 110-799 Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Seoul</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0470 5905</institution-id><institution-id institution-id-type="GRID">grid.31501.36</institution-id><institution>Institute of Medical and Biological Engineering, Medical Research Center,</institution><institution>Seoul National University College of Medicine, Yongon-Dong,</institution></institution-wrap>Seoul, 110-799 Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Seoul</wicri:regionArea></affiliation></author></analytic><series><title level="j">Scientific Reports</title><idno type="eISSN">2045-2322</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="Par1">Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death, necessitating the discovery of serum markers for its early detection. In this study, a total of 180 serum samples from liver cirrhosis (LC), hepatocellular carcinoma (HCC) patients and paired samples of HCC patients who recovered (Recovery) were analyzed by multiple reaction monitoring-mass spectrometry (MRM-MS) to verify biomarkers. The three-fold crossvalidation was repeated 100 times in the training and test sets to evaluate statistical significance of 124 candidate proteins. This step resulted in 2 proteins that had an area under the receiver operating curve (AUROC) values ≥0.800 in the training (n = 90) and test sets (n = 90). Specifically, fibronectin (FN1, WCGTTQNYDADQK), distinguished HCC from LC patients, with an AUROC value of 0.926 by logistic regression. A FN1 protein was selected for validation in an independent sample (n = 60) using enzyme-linked immunosorbent assay (ELISA). The combination of alpha-fetoprotein (AFP) and FN1 improved the diagnostic performance and differentiated HCC patients with normal AFP levels. Our study has examined candidate markers for the benign disease state and malignancy and has followed up on the consequent recovery. Thus, improvement in the early detection of HCC by a 2-marker panel (AFP + FN1) might benefit HCC patients.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Lafaro, Kj" uniqKey="Lafaro K">KJ Lafaro</name></author><author><name sortKey="Demirjian, An" uniqKey="Demirjian A">AN Demirjian</name></author><author><name sortKey="Pawlik, Tm" uniqKey="Pawlik T">TM Pawlik</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Forner, A" uniqKey="Forner A">A Forner</name></author><author><name sortKey="Llovet, Jm" uniqKey="Llovet J">JM Llovet</name></author><author><name sortKey="Bruix, J" uniqKey="Bruix J">J Bruix</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fuchs, Bc" uniqKey="Fuchs B">BC Fuchs</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, Dy" uniqKey="Zhang D">DY Zhang</name></author><author><name sortKey="Friedman, Sl" 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uniqKey="Hilgenfeldt E">E Hilgenfeldt</name></author><author><name sortKey="Mitra, A" uniqKey="Mitra A">A Mitra</name></author><author><name sortKey="Cabrera, R" uniqKey="Cabrera R">R Cabrera</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cong, Wm" uniqKey="Cong W">WM Cong</name></author><author><name sortKey="Wu, Mc" uniqKey="Wu M">MC Wu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="El Serag, Hb" uniqKey="El Serag H">HB El-Serag</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wong, R" uniqKey="Wong R">R Wong</name></author><author><name sortKey="Frenette, C" uniqKey="Frenette C">C Frenette</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bialecki, Es" uniqKey="Bialecki E">ES Bialecki</name></author><author><name sortKey="Di Bisceglie, Am" uniqKey="Di Bisceglie A">AM Di Bisceglie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sherman, M" uniqKey="Sherman M">M Sherman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hudler, P" uniqKey="Hudler P">P Hudler</name></author><author><name sortKey="Kocevar, N" uniqKey="Kocevar N">N Kocevar</name></author><author><name sortKey="Komel, R" uniqKey="Komel R">R Komel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hanash, Sm" uniqKey="Hanash S">SM Hanash</name></author><author><name sortKey="Pitteri, Sj" uniqKey="Pitteri S">SJ Pitteri</name></author><author><name sortKey="Faca, Vm" uniqKey="Faca V">VM Faca</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gillette, Ma" uniqKey="Gillette M">MA Gillette</name></author><author><name sortKey="Carr, Sa" uniqKey="Carr S">SA Carr</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mann, M" uniqKey="Mann M">M Mann</name></author><author><name sortKey="Kulak, Na" uniqKey="Kulak N">NA Kulak</name></author><author><name sortKey="Nagaraj, N" uniqKey="Nagaraj N">N Nagaraj</name></author><author><name sortKey="Cox, J" uniqKey="Cox J">J Cox</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kennedy, Jj" uniqKey="Kennedy J">JJ Kennedy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Meng, Z" uniqKey="Meng Z">Z Meng</name></author><author><name sortKey="Veenstra, Td" uniqKey="Veenstra T">TD Veenstra</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Percy, Aj" uniqKey="Percy A">AJ Percy</name></author><author><name sortKey="Chambers, Ag" uniqKey="Chambers A">AG Chambers</name></author><author><name sortKey="Yang, J" uniqKey="Yang J">J Yang</name></author><author><name sortKey="Hardie, Db" uniqKey="Hardie D">DB Hardie</name></author><author><name sortKey="Borchers, Ch" uniqKey="Borchers C">CH Borchers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Percy, Aj" uniqKey="Percy A">AJ Percy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rai, Aj" uniqKey="Rai A">AJ Rai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Addona, Ta" uniqKey="Addona T">TA Addona</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chambers, Ag" uniqKey="Chambers A">AG Chambers</name></author><author><name sortKey="Percy, Aj" uniqKey="Percy A">AJ Percy</name></author><author><name sortKey="Simon, R" uniqKey="Simon R">R Simon</name></author><author><name sortKey="Borchers, Ch" uniqKey="Borchers C">CH Borchers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stein, Se" uniqKey="Stein S">SE Stein</name></author><author><name sortKey="Scott, Dr" uniqKey="Scott D">DR Scott</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yen, Cy" uniqKey="Yen C">CY Yen</name></author><author><name sortKey="Houel, S" uniqKey="Houel S">S Houel</name></author><author><name sortKey="Ahn, Ng" uniqKey="Ahn N">NG Ahn</name></author><author><name sortKey="Old, Wm" uniqKey="Old W">WM Old</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Abbatiello, Se" uniqKey="Abbatiello S">SE Abbatiello</name></author><author><name sortKey="Mani, Dr" uniqKey="Mani D">DR Mani</name></author><author><name sortKey="Keshishian, H" uniqKey="Keshishian H">H Keshishian</name></author><author><name sortKey="Carr, Sa" uniqKey="Carr S">SA Carr</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Choi, M" uniqKey="Choi M">M Choi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Maurer, Lm" uniqKey="Maurer L">LM Maurer</name></author><author><name sortKey="Ma, W" uniqKey="Ma W">W Ma</name></author><author><name sortKey="Mosher, Df" uniqKey="Mosher D">DF Mosher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tamkun, Jw" uniqKey="Tamkun J">JW Tamkun</name></author><author><name sortKey="Hynes, Ro" uniqKey="Hynes R">RO Hynes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roy, Dc" uniqKey="Roy D">DC Roy</name></author><author><name sortKey="Hocking, Dc" uniqKey="Hocking D">DC Hocking</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schmidt, G" uniqKey="Schmidt G">G Schmidt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hubbard, B" uniqKey="Hubbard B">B Hubbard</name></author><author><name sortKey="Buczek Thomas, Ja" uniqKey="Buczek Thomas J">JA Buczek-Thomas</name></author><author><name sortKey="Nugent, Ma" uniqKey="Nugent M">MA Nugent</name></author><author><name sortKey="Smith, Ml" uniqKey="Smith M">ML Smith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Johansson, S" uniqKey="Johansson S">S Johansson</name></author><author><name sortKey="Hook, M" uniqKey="Hook M">M Hook</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Aota, S" uniqKey="Aota S">S Aota</name></author><author><name sortKey="Nomizu, M" uniqKey="Nomizu M">M Nomizu</name></author><author><name sortKey="Yamada, Km" uniqKey="Yamada K">KM Yamada</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Aziz Seible, Rs" uniqKey="Aziz Seible R">RS Aziz-Seible</name></author><author><name sortKey="Casey, Ca" uniqKey="Casey C">CA Casey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Singh, P" uniqKey="Singh P">P Singh</name></author><author><name sortKey="Schwarzbauer, Je" uniqKey="Schwarzbauer J">JE Schwarzbauer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Veevers Lowe, J" uniqKey="Veevers Lowe J">J Veevers-Lowe</name></author><author><name sortKey="Ball, Sg" uniqKey="Ball S">SG Ball</name></author><author><name sortKey="Shuttleworth, A" uniqKey="Shuttleworth A">A Shuttleworth</name></author><author><name sortKey="Kielty, Cm" uniqKey="Kielty C">CM Kielty</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brentnall, M" uniqKey="Brentnall M">M Brentnall</name></author><author><name sortKey="Weir, Db" uniqKey="Weir D">DB Weir</name></author><author><name sortKey="Rongvaux, A" uniqKey="Rongvaux A">A Rongvaux</name></author><author><name sortKey="Marcus, Ai" uniqKey="Marcus A">AI Marcus</name></author><author><name sortKey="Boise, Lh" uniqKey="Boise L">LH Boise</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Astrof, S" uniqKey="Astrof S">S Astrof</name></author><author><name sortKey="Hynes, Ro" uniqKey="Hynes R">RO Hynes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhou, X" uniqKey="Zhou X">X Zhou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jerhammar, F" uniqKey="Jerhammar F">F Jerhammar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cao, Y" uniqKey="Cao Y">Y Cao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yim, Sy" uniqKey="Yim S">SY Yim</name></author><author><name sortKey="Ryu, E" uniqKey="Ryu E">E Ryu</name></author><author><name sortKey="Lim, Jy" uniqKey="Lim J">JY Lim</name></author><author><name sortKey="Yang, Ej" uniqKey="Yang E">EJ Yang</name></author><author><name sortKey="Lee, Sm" uniqKey="Lee S">SM Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yaqoob, U" uniqKey="Yaqoob U">U Yaqoob</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Uhlen, M" uniqKey="Uhlen M">M Uhlen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Torbenson, M" uniqKey="Torbenson M">M Torbenson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Matsui, S" uniqKey="Matsui S">S Matsui</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Szendroi, M" uniqKey="Szendroi M">M Szendroi</name></author><author><name sortKey="Lapis, K" uniqKey="Lapis K">K Lapis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tuck, Mk" uniqKey="Tuck M">MK Tuck</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vivo Truyols, G" uniqKey="Vivo Truyols G">G Vivo-Truyols</name></author><author><name sortKey="Schoenmakers, Pj" uniqKey="Schoenmakers P">PJ Schoenmakers</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Prentice, R" uniqKey="Prentice R">R Prentice</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Corée du Sud</li></country></list><tree><country name="Corée du Sud"><noRegion><name sortKey="Kim, Hyunsoo" sort="Kim, Hyunsoo" uniqKey="Kim H" first="Hyunsoo" last="Kim">Hyunsoo Kim</name></noRegion><name sortKey="Jong Yu, Su" sort="Jong Yu, Su" uniqKey="Jong Yu S" first="Su" last="Jong Yu">Su Jong Yu</name><name sortKey="Kim, Hyunsoo" sort="Kim, Hyunsoo" uniqKey="Kim H" first="Hyunsoo" last="Kim">Hyunsoo Kim</name><name sortKey="Kim, Hyunsoo" sort="Kim, Hyunsoo" uniqKey="Kim H" first="Hyunsoo" last="Kim">Hyunsoo Kim</name><name sortKey="Kim, Yongkang" sort="Kim, Yongkang" uniqKey="Kim Y" first="Yongkang" last="Kim">Yongkang Kim</name><name sortKey="Kim, Youngsoo" sort="Kim, Youngsoo" uniqKey="Kim Y" first="Youngsoo" last="Kim">Youngsoo Kim</name><name sortKey="Kim, Youngsoo" sort="Kim, Youngsoo" uniqKey="Kim Y" first="Youngsoo" last="Kim">Youngsoo Kim</name><name sortKey="Kim, Youngsoo" sort="Kim, Youngsoo" uniqKey="Kim Y" first="Youngsoo" last="Kim">Youngsoo Kim</name><name sortKey="Park, Jiyoung" sort="Park, Jiyoung" uniqKey="Park J" first="Jiyoung" last="Park">Jiyoung Park</name><name sortKey="Park, Taesung" sort="Park, Taesung" uniqKey="Park T" first="Taesung" last="Park">Taesung Park</name><name sortKey="Sohn, Areum" sort="Sohn, Areum" uniqKey="Sohn A" first="Areum" last="Sohn">Areum Sohn</name><name sortKey="Yeo, Injun" sort="Yeo, Injun" uniqKey="Yeo I" first="Injun" last="Yeo">Injun Yeo</name><name sortKey="Yoon, Jung Hwan" sort="Yoon, Jung Hwan" uniqKey="Yoon J" first="Jung-Hwan" last="Yoon">Jung-Hwan Yoon</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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